Phagocytosis in Fungus Infection
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概要
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The study of phagocytosis of Candida albicans and Cryptococcus neoformans by human, guinea pig and mouse peripheral blood leukocytes (PBL) and guinea pig and mouse peritoneal macrophages (PMP) in vitro has been performed to elucidate the role of phagocytosis in host defense mechanism against systemic mycoses. Although C. albicans was ingested by guinea pig and mouse PBL and PMP in the same rates in the presense of fresh serum, the killing rates of intracellular C. albicans in these phagocytes were not the same showing a high ability of guinea pig and a low of mouse phagocytes. The human PBL showed an intermediate killing ability between them. Moreover, intracellular killing abilities of guinea pig and mouse PMP were lower than those of PBL. The killing capacity of mouse PMP increased remarkably when the PMP had been cultured previousely with lymphokines for 3 days. The PBL and PMP ingested C. albicans almost completely in the presense of fresh serum alone, and no more enhancement of ingestion was shown when specific antibody was added to this system. The results of phagocytosis in vitro using EGTA and Mg++ indicate that normal opsonin for C. albicans is factors of properdin system in fresh serum. Guinea pig PBL and PMP ingested encapsulated strain of C. neoformans more effectively than nonencapsulated strain, and specific antibody did not enhance ingestion of both strains of C. neoformans. It might been suggested that properdin system and PMP play an important role at the primary stage of Candida or Cryptococcal infections and that activated macrophages participate in the host defense mechanism after induction of sensitized lymphocytes.
- 日本医真菌学会の論文
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