Trichothecenes produced by Fusarium species Fn 2B
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概要
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The production of trichothecene mycotoxins in Fusarium sp. Fn 2 (NRRL 3509), originally identified as F. nivale was reexamined in details. Shake flask cultures with peptone-sucrose-yeast extract medium produced fusarenon-X (FX=4-acetyl-nivalenol) and diacetoxyscirpenol (DAS) as major products, along with other trichothecenes as minor products, including some tentatively identified as 9-hydroxy-trichotriol, sambucoin, 13-hydroxy-11-epi-apotrichothecene, verrucarol and FS-1. In rice cultures, the major metabolites found were nivalenol (NIV) and FX. Of these toxins, DAS has the highest toxicity towards mammalian cells followed by FX and NIV. The present data revealed that strain Fn 2B produces both the type A (DAS) and type B (NIV/FX) trichothecenes, as observed in F. poae.
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