The effect of aflatoxin B<SUB>1</SUB> on cultured hepatocytes originated from chick-embryo and rat
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The effect of aflatoxin B<SUB>1</SUB> (Af B<SUB>1</SUB>) on the cultured hepatocytes originated from either chick-embryos or rats was studied. Hepatocytes originated from male adult rats (mean body weight 150 g) were most sensitive to Af B<SUB>1</SUB>. In contrast, those from chick-embryos were about 1/1000 less sensitive than rat heptocytes to the mycotoxin. Microsomal fractions prepared from the livers of rats fed with PCB increased the sensitivity of chick-embryonal hepatocytes markedly. Fibroblasts isolated from 10 day-old chick-embryos were the most resistant to Af B<SUB>1</SUB>. From the results of present studies it may be postulated that enzymes of cytochrom-P-450 system may play an important role also in acute cytotoxicity.
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