Studies on the positive T Wave on ECG in the Rat-Based on the Analysis for Direct Cardiac Electrograms in the Ventricle
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概要
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In order to obtain direct evidence of the genesis of "positive" T wave on the standard limb lead II electrocardiogram (ECG) in the rat, ventricular activation and its recovery patterns were investigated by recording direct cardiac electrograms. Multiple unipolar electrograms were recorded from 7 sites in the left ventricle including the septum, subendocardium and subepicardium under the constant sinus rhythms in 12rats. The unipolar electrograms and their differentiated waves were analyzed for local QT intervals and local activation times, respectively. In addition, the direct bipolar electrograms between the subendocardium and the subepicardium of the left ventricle were also recorded in 6 rats. The proceeding times from the septum (initial) to the subepicardium (terminal) were very short as less than 10 msec. Nevertheless, the activation sequence in the left ventricle was clearly shownin accordance to the following order ; the septum, subendocardium and subepicardium. The local QT intervals in the subepicardial sites were significantly shorter than those in the corresponding subendocardial sites (p<0.05). These activation sequences and local QT intervals in the rat ventricle suggest a presence of transmural gradient of depolarization and repolarization, with an earlier depolarization at the endocardium and with an earlier repolarization at the epicardium. Such a transmural gradient might produce an electrical dipole which would contribute to the configuration of positive T wave on the rat ECG. In fact, the positive waves recorded by the direct bipolar electrograms between the subendocardia and the subepicardia can account for the formation of an electrical dipole having a positive charge at the subepicardia against the subendocardia.
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