Effects of dobutamine on the hepatic circulation in dogs.

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Effect of intravenous infusion of dobutamine on hepatic circulation at doses of 5, 10, and 15μg/kg/min were studied in 6 mongrel dogs under pentobarbital sodium anesthesia. Hepatic arterial and portal venous blood flows were measured. Dobutamine increased the heart rate and the cardiac index, but decreased the systemic vascular resistance with a dose-dependence. Each dose of dobutamine did not change the mean arterial pressure. The 5μg/kg/min-adminstered group demonstrated an increased total hepatic blood flow accompanied by increased hepatic arterial and portal venous blood flows. The 10μg/kg/min-administered group showed an increased total hepatic blood flow accompanied by an increased portal venous blood flow with no change in hepatic arterial blood flow. The 15μg/kg/min-infused group showed an increased total hepatic blood flow accompanied by an increased portal venous blood flow and a decreased hepatic arterial blood flow. Portal and hepatic venous pressures were not changed with no relation to dose-dependence. Hepatic oxygen supply was increased with a dose-dependence, but the hepatic oxygen consumpution was maintained at the control level. Hepatic oxygen extraction ratio was decreased with a dose-dependence. To summarize the data, dobutamine significantly improves the hepatic circulation, accompanied by a hepatic oxygen supply increment.
日本獣医循環器学会の論文