Effects of dopamine on the hepatic circulation in the dog.
スポンサーリンク
概要
- 論文の詳細を見る
We studied the effects of the intravenous infusion of dopmine on hepatic circulation at doses of 3, 7 and 15μg/kg/min. Six mongrel dogs weighing 19.1±6.1kg were studied under sodium pentobarbital anesthesia. Cardiac output was measured by thermodilution methods. Portal venous blood flow (PVBF) and hepatic arterial blood flow (HABF) were measured by an electromagnetic flowmeter. Hepatic oxygen supply and consumption were calculated from the blood flow and the oxygen contents.<BR>Dopamine at all doses caused a significant increase in PVBF and a significant decrease in HABF. However, dopamine at doses of 3 and 7μg/kg/min demonstrated no significant changes in the total hepatic blood flow (THBF). Dopamine at a dose of 3μg/kg/min showed no effects on the hepatic and systemic oxygen supply-demand relationship. Dopamine at a dose of 7μg/ kg/min resulted in increased in the systemic oxygen supply and consumption under a fixed oxygen extraction ratio. Dopamine at a dose of 15μg/kg/min caused a significant increase in THBF accompanied by an increased systemic oxygen consumption and an increased systemic oxygen extraction ratio.<BR>From these results, it is suggested that dopamine at doses of 3 and 7μg/kg/min has minimum effects on the hepatic circulation and oxygen supply-demand relationship, but that dopamine at a dose of 7μg/kg/min is the most effective for improvement of the systemic circulation and oxygen supply-demand relationship.
- 日本獣医循環器学会の論文
日本獣医循環器学会 | 論文
- ヒトの特発性心筋症の遺伝子解析
- 遺伝子診断法
- 部分内臓逆位, 肝部後大静脈欠損および奇静脈連結を伴う静脈管開存症の犬の1例
- 右前大静脈欠損を伴う左前大静脈遺残の犬の一例
- 長期観察が可能であった猫拡張型心筋症の1例