Effects of Intravenous Injection of Penicillin G Potassium and Penicillin G Sodium on Serum Electrolyte and Electrocardiogram in Dogs

概要

論文の詳細を見る
This study was performed to assess the effect of an intravenous injection of large doses of penicillin G salt form on serum electrolyte and electrocardiogram in dogs. Eighteen beagle dogs (age: 8-22 months, body weight: 7-10.5 kg) were given intravenously 3.5×105 I. U./kg and 7×105 I. U./kg of penicillin G potassium or penicillin G sodium. The injection volume was 2.4 ml/kg body weight and the injection speed was 4-5 ml/min. During the intravenous injection of 7×105 I. U./1. 2 mEq (equivalent to K++)/kg of penicillin G potassium, vomiting and convulsion were observed, and an elevation of T waves, a prolongation of QRS complex and a depression of ST segment were noted on the electrocardiogram. The injection was obliged to be stopped in 2 out of 4 dogs, since these 2 dogs showed the disappearance of P wave 3-4 min after the onset of injection. On the other hand, during the intravenous injection of 7×105 I. U./1.2 mEq (equivalent to Na++)/kg of penicillin G sodium, vomiting only was observed, and changes in ECG were smaller as compared with those induced by penicillin G potassium. Changes in serum K+ and Na++ concentration after injection of penicillin G potassium or penicillin G sodium remained within the normal range. The changes during and after the intravenous administration of penicillin G potassium and penicillin G sodium were very similar qualitatively and quantitatively to those induced by the equivalent dosing of KCl and NaCl. From the foregoing results it is concluded that the cardiac effects of penicillin G potassium or sodium are mainly due to those K+ or Na+ contained in them, and that penicillin G sodium is safer in clinical use than penicillin G potassium.
日本獣医循環器学会の論文

Effects of Intravenous Injection of Penicillin G Potassium and Penicillin G Sodium on Serum Electrolyte and Electrocardiogram in Dogs

スポンサーリンク

概要

日本獣医循環器学会 | 論文

スポンサーリンク