Atrial Natriuretic Peptide in Cattle with Atrial Fibrillation
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概要
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Atrial natriuretic peptide (ANP) in the plasma of cattle with atrial fibrillation (Af) was investigated. Plasma ANP concentration in the cattle with Af was highly increased (118.0±44.0 (SD) pg/ml, n=5 as compared with that in the control (43.4±5.28 pg/ml, n=12, p<0.05). After defibrillation by oral of administration, quinidine a significant decrease in plasma ANP concentration was observed (41.1±6. 06 pg/ml, p<0.05), the concentration being similar to that in the control. Gel permeation chromatogram of plasma ANP showed a single peak corresponding to the elution position of authentic α-hANP in plasma during Af and after defibrillation. These results indicate that the excretion of ANP from the heart is was enhanced without alteration of the molecular from of ANP.
- 日本獣医循環器学会の論文
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