Plasma and Tissue Distribution of Quinidine Sulfate Administered by Various Routes in Cows

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The pharmacokinetics of quinidine was studied by using 12 diseased cows after oral or intravenous administration of this drug. Plasma and major body tissue concentrations the of quinidine were quantitatively analyzed postmortem by the double extraction method. A series of oral doses with decreasing dosage were most effective in maintaining the therapeutic plasma concentrations and thus considered to be the safest. Since there was a correlation between myocardium and plasma concentrations of quinidine (r=0.768), it might be possible to estimate the myocardial concentration of this drug from its plasma concentration. After intravenous or oral administration, quinidine was detected in the brain, suggesting that it might be associated with development of cinchonism as an immediate cause. In a pregnant cow, orally administered quinidine was found in the fetus, suggesting a transplacental transfer of this drug.
日本獣医循環器学会の論文