Vectorcardiographic Study on Cardiac Hypertrophy in SHR (McFee-Parungao Lead System)

概要

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To examine vectorcardiography of left ventricular hypertrophy (LVH) in a spontaneously hypertensive rat (SHR), vectorcardiogram (VCG) was recorded from ten 30-week-old SHRs and ten age-matched Wistar rats (WR) by applying McFee-Parungao lead system for the dog.<BR>Arterial blood pressure (BP) was 113.25±11.83mmHg in WR and 188.43±19.17 mmHg in SHR. VCG was recorded by McFee-Parungao lead system in restrained ventral position after being anesthetized with urethan-chloralose. VCG was measured on the following parameters; orientation, magnitude and time of maximum QRS vector (Max QRSv), orientation and magnitude of maximum T vector (Max Tv), QRS-T angle and ratio of T/QRS.<BR>VCG in SHR was characterized by superior, posterior and leftward shift of QRS loop, prolongation of time of Max QRSv, and an increase of QRS-T angle in all planes. These observations of VCG in SHR were very similar to those of LVH due to pressure overloading in humans.
日本獣医循環器学会の論文