Control of systemic hypertension in the acute stage of hypertensive intracerebral hemorrhage and ruptured aneurysm:With special reference to the effectiveness of metoprolol
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We investigated the effects of metoprolol, propranolol and phentolamine on hemodynamic conditions, arterial norepinerphrine and epinephrine levels, renin activity, and renal plasma flow in 6 patients with ruptured intracranial aneurysm and 2 patients with hypertensive putaminal hemorrhage suffering from systemic arterial hypertension. Phentolamine was a potent antihypertensive, but increased intracranial pressure. Propranolol, a non-selective β blocker, reduced renal plasma flow. However, metoprolol, a cardioselective β<SUB>1</SUB> blocker, did not decrease renal plasma flow, but did reduce arterial norepinephrine, epinephrine levels, and renin activity. Moreover, the agent did not influence intracranial pressure and cerebral perfusion pressure. Our findings indicate that metoprolol can be safely used as an antihypertensive drug to control acute systemic arterial hypertension in patients with intracranial mass lesions and/or intracranial hypertension.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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