Analysis of the pathophysiology of the coagulation and fibrinolytic systems following stroke by measuring plasma fibrinopeptides
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概要
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Elevated plasma concentrations of fibrinopeptide A (FPA) and fibrinopeptide Bβ<SUB>15-42</SUB> (FPBβ) are direct evidence for enhanced thrombin and plasmin activities in plasma respectively. Plasma FPA and FPBβ levels were measured serially following stroke by specific radioimmunoassays in 19 patients with cerebral hemorrhage and 30 patients with cerebral infarction. Based on the findings of cranial computerized tomography, patients with cerebral infarction were divided into 2 subtypes : main trunk artery type and deep branch artery type infarction.<BR>In patients with cerebral hemorrhage, FPA levels were greatly elevated and exceeded FPBβ levels immediately following stroke. This was followed by a rapid increase in FPBβ levels, with peak FPBβ levels occurring on the 1st day after ictus.<BR>In patients with main trunk artery type infarction, FPBβ levels were mildly to moderately elevated and exceeded FPA levels immediately following stroke. FPA levels increased gradually and peaked on the 3rd day after ictus only in patients with stroke progression. In contrast, FPA levels did not increase with time in patients who remained stable.<BR>In patients with deep branch artery type infarction, no significant changes in both FPA and FPBβ levels were observed following stroke.<BR>These results suggest that the pattern of plasmin activity following thrombin activity after cerebral hemorrhage may represent a common hemostatic response to injury, and also that the pattern of gradual increase of thrombin activity after main trunk artery type infarction may represent stroke progression closely associated with development of thrombus formation.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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