Changes in 5'-nucleotidase activity in cerebral arteries of rats with experimental cerebral ischemia
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Rats with experimental cerebral ischemia were prepared by clipping bilateral carotid arteries for 30 minutes after bilateral vertebral arteries of Wistar rats had been electrocauterized. The activity of 5'-nucleotidase was measured quantitatively in brain homogenate and also demonstrated histochemically. The activity of 5'-nucleotidase was detected mainly in the pia mater and slightly in the white matter, but not in the arterial wall of Wistar rats which received a sham operation. The enzyme activity was demonstrated also in the surrounding part of cerebral arteries in rats which showed a complete paralysis brought about by the occulusion of four vessels.<BR>The activity of 5'-nucleotidase in brain homogenate was significantly higher in rats with a complete paralysis (29.8 ± 5.2 nmoles/mg protein/min) than either in rats without paralysis (23.3 ± 3.8 nmoles/mg protein/min) or in rats with a sham operation (22.0± 4.1 nmoles/mg protein/min) (p<0.05).<BR>These results suggest that adenosine is produced by the increased activity of 5'-nucleotidase in the periarterial region of rats with cerebral ischemia and adenosine would cause a dilatation of arteries as a compensatory mechanism for cerebral ischemia.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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