An experimental study of cerebral infarction:II. Biochemical study of neutral lipids and brain macrophages
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This study deals with the metabolism of neutral lipids in experimentally produced cerebral infarcts in rats. A biochemical analysis of the lesions was carried out chronologically at various stages of the lesions in order to know what constituents of the neutral lipids are present and also to know where and how the neutral lipids are metabolized in the pathological conditions.<BR>The results lead us to the following conclusions;<BR>1. Neutral lipids that were increased in the lesions were made up of cholesterol esters (ChE), free fatty acids (FFA) and triglycerides (TG). The accumulation of ChE was most prominent at 14 days old infarcts, occupying up to 14% of the total amounts of the lipids. Further, both ChE and FFA remained in considerably high amounts at 40 and 100 days old infarcts, when the lesions were well healed.<BR>2. Lipid analysis in macrophages isolated from the lesions suggested that the neutral lipids were mainly metabolized in these cells especially at the early stage of the infarcts, and also suggested that the increase of the neutral lipids in pathological condition depends upon the metabolic activity of macrophages.<BR>3. There was a considerable difference in fatty acid composition of ChE between recent and old infarcts. ChE in old infarcts had a relative high ratio of longer chained fatty acids ranging from C22 to C28 as compared with the recent ones. It might be therefore concluded that the variations of fatty acid composition of ChE are related to the stage of the injury; namely, the older the lesions the higher the ratio of longer chained fatty acids to the total amounts of fatty acids of ChE is obtained.<BR>4. Increased neutral lipids appear to have an important effect on the evolution and healing process of cerebral infarcts.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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