Current status and future of EC-IC bypass surgery-JET study, JET-2 study, JAM Trial
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概要
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Since 1985, when the efficacy of the extracranial-intracranial (EC-IC) bypass surgery on stroke prevention was denied by the randomized multi-center trial, the number of bypass surgery for stroke prevention had drastically decreased all over the world. Recent development of quantitative cerebral blood flow (CBF) measurement, however, has made it possible to examine efficacy of bypass surgery for specific groups of cerebrovascular insufficiency.<BR>Japanese EC-IC bypass surgery trial (JET) focused on the efficacy of bypass for the stage II ischemia, and now established significantly lower recurrence rate in the bypass-surgery group than the medical treatment group. JET-2 study, now in progress, is designed to examine stroke recurrence rate on medical treatment for the stage I ischemia, classified into 4 subgroups based on cerebrovascular reserve capacity and rest CBF value, and will establish whether there is potential candidate in the stage I ischemia who benefit from bypass surgery for stroke prevention. Japan Adult Moyamoya (JAM) Trial is a multi-center randomized trial designed to answer the efficacy of bypass surgery for secondary prevention of hemorrhagic stroke in adult patients with moyamoya disease of hemorrhagic presentation. These Japanese multi-center studies will herald a new era of bypass surgery for stroke prevention after longstanding darkness since 1985.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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