Expression of adhesion molecules of circulating lymphocytes (LFA-1, VLA-4) and endothelial cells (ICAM-1, VCAM-1) increases in patients with chronic cerebral infarction
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Adhesion molecules of circulating leukocytes and endothelial cells play an important role in the pathogenesis of acute cerebral infarction. We reported previously that the expression of lymphocyte adhesion mole-cules, LFA-la. β(CDI la bright and CD18 bright), increases from the acute phase to chronic phase of the disease. In the present study, 40 patients with chronic lacunar infarction and 25 age-mathed controls were inves-tigated, employing immunofluorescence flow cytometry and ELISA to measure the lymphocyte membrane expression of LFA-lα(CD11a bright), LFA-1β (CD18 bright), VLA-4α(CD49d) and VLA-4β(CD29 bright), and the plasma levels of soluble (s) ICAM-1 and sVCAM-1, which are ligands for LFA-1 and VLA-4. The rela-tionships between the adhesion molecules and risk factors of cerebrovascular disease were analyzed. The ex-pression of LFA-la, R and the level of sICAM-1 showed a significant increase in the patients as compared to the controls (p<0.01, p<0.05, and p<0.001, respectively). Although there was no siginificant difference in the case of VLA-4, the level of sVCAM-1 was significantly higher in the patients than in the controls (p<0.0001). The expression of LFA-la, R tended to be increased in smokers, as was the level of sVCAM-1 in diabetics and smokers. It seems likely that the local vascular lesions are chronically affected by repetition of ischemic reper-fusion in the chronic phase of cerebral infarction, so that the expression of adhesion molecules of endothelial cells (ICAM-1, VCAM-1) increases and, thereby, the expression of adhesion molecule of lymphocytes (LFA-1) increases.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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