Clinical significance and modification of plasma basic fibroblast growth factor levels in patients at the acute and chronic phases of cerebral infarction.
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We measured the plasma basic fibroblast growth factor (bFGF) antigen levels of patients at the acute and chronic phases of cerebral infarction. Cerebral infarction was classified into 3 groups : the atherothrombotic brain infarction (AI) group, lacunar infarction (LI) group, and cardiogenic embolism (CE) group. The clinical significance of the plasma bFGF levels was compared among these subjects. The plasma bFGF levels in each of the three groups were elevated as compared to those of the control group at the 1 st and 7 th days of hospitalization. The plasma bFGF levels in the AI and LI groups revealed a tendency to decrease between the 1 st and 7 th hospital days, while that of the CE group tended to increase during the same period. The plasma bFGF levels were still elevated in each of the three groups as compared to the control group at the chronic phase. Postulating that the elevation of the plasma bFGF at the acute phase might reflect its release from the ischemic brain tissue, we examined the relation between the 1 st and 7 th day plasma bFGF levels and the size of the area of infarction. However, no correlation was found between them. Elevation of the plasma bFGF levels at the acute phase might represent a reaction of a more general systemic nature.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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