Fatal brain edema induced by a combination of intraventricular hemorrhage and bilateral carotid artery occlusion in the rat.
スポンサーリンク
概要
- 論文の詳細を見る
The prognosis of intraventricular hemorrhage (IVH) differes among patients with similar volumes of intraventricular hematoma. We hypothesized that the prognosis of IVH is poor when the decrease in cerabral blood flow (CBF) lasts for a long duration as a result of severe global ishemia, mainly due to an instant rise in intracranial pressure at the time bleeding. To mimic the clinical condition of IVH with a prolonged decrease in CBF, we subjected rats to intraventricular blood administration combined with bilateral carotid artery occlusion (BACO). In order to attain long-lasting but nonlethal hypoperfusion within the brain, we ligated the right and the left caroitd arteries at a 7-day interval, and found that over 90% of the rats immediately became active on recovery from halothane anesthesia and that all of these rats survived At one hour after completion of BCAO, only active rats were anesthetized again and subjected to intraventricular injection of 40 μ1 of non-heparinized autologous blood. Forty-five percent of the rats remained lethargic and died within 16 hours following the surgery, as a result of severe brain edema. In contrast, all surviving rats exhibited no significant brain edema following intraventricular blood injection only, BCAO only, or intraventricular saline injection combined with BCAO. These findings suggest that fatal brain edema is oftern induced when IVH is accompanied by a moderate but long-lasting decrease in CBF.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
- Two cases with aphasia in the left putaminal damage and one case with visuospatial neglect in the right putaminal damage
- Alterations of plasma von Willebrand factor activity and the influence of anti-platelet drugs in acute cerebral infarction
- Carotid endarterectomy plaques correlation of clinical events and morphology.
- Stenting for stenosis of major cerebrovascular arteries.
- Cerebral infarction following antihypertensive therapy.