Monitoring of the antifibrinolytic therapy in acute phase of SAH (Availability of t-AMCA score)
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概要
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Fcr the purpose of deciding the minimum dose of antifibrinolytic agent for the conservative treatment of subarachnoid hemorrhage (SAH) in acute phase, we developed a method which was able to measure reduction in fibrinolytic activity of cerebrospinal fluid (CSF) within a short period of time. It was reproducible, and its value was expressed as t-AMCA score. CSF was collected every 30 minutes or six hours in nine cases of SAH who had been treated with an antifibrinolytic agent (t-AMCA) in a daily dose of 4-6 gram and the t-AMCA score obtained was compared with the dosage, t-AMCA concentration in the CSF, FDP in the CSF and daily excretion volume of CSF through the drainage.<BR>It resulted in that the concentration of antifibrinolytic agent in the CSF was negativery correlated to the daily excretion volume of CSF, and revealed accumulation effect. The t-AMCA score usualy changed in a constant pattern for a term of administration, showed rebound fibrinolysis in the two hours after the administration and at the three days after the withdrawal, and revealed very increased fibrinolytic activity around the one week after the onset. FDP in the CSF was traced when the t-AMCA score had been continued over 5 more than 12 hours, and contrary it appeared when the t-AMCA score had been continued under 4 over 6 hours.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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