Clinical study on cognitive function in silent cerebral infarction with diabetes mellitus.
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概要
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The purpose of the present study was to determine whether or not a neuropsychological battery of examinations could demonstrate abnormalities in diabetic patients with silent cerebral infarction and which examinations were the most useful for screening such abnormalities. In addition, we analyzed whether or not diabetic microangiopathy (retinopathy, nephropathy, and neuropathy), hypertension and aging affected the scores on the neuropsychological battery. We classified 48 diabetic patients into three groups according to ther magnetic resonance imaging (MRI) findings, as follows : 16 cases with no infarction (Grade 0 : G0), 12 cases with a few lacunar infarctions (Grade 1 : G1), and 20 cases with over 5 lacunar infarctions (Grade 2 : G2). Five neuropsychological examinations (the mini mental state examination (MMS-E), word fluency test, digit span, modified Stroop test, and Kana-Hiroi examination) were applied to the diabetic patients. Although the MMS-E revealed no difference in scores among the three groups, the digit span and word fluency tests showed declines in scores, which correlated with the deterioration seen on MRI. On the other hand, aging and complication of microangiopathy or hyperension did not significantly affect the scores on the neuropsychological battery regardless of the MRI findings. The present data revealed that some diabetic patients with silent cerebral infarction had mild neuropsychological abnormalities and that both the digit span and word fluency tests were the most useful for screening such mild neuropsychological abnormalities.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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