Plasma levels of prothrombin fragment 1+2(F1+2) in symptomatic lacunar infarction and asymptomatic lacunar infarction.
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概要
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To clarify the possible contribution of coagulation activation to the development of lacunar infarction, we measured the plasma levels of prothrombin fragment 1+2 (F<SUB>1+2</SUB>), a molecular marker of coagulation activation, in 61 patients with symptomatic lacunar infarction (acute stage, A group, N=26, chronic stage, C group, N=35), 34 patients with asymptomatic lacunar infarction (AS group), and 67 subjects without any central nervous system symptoms and no abnormal findings on MRI (N group). The mean systolic blood pressure on admission was significantly higher in the A group than in the N group (p<0.05). The prevalence and history of hypertension was significantly higher in the A group (53.8%) and the AS group (38.2%) than in the N group (14.9%) (p<0.01 and p<0.05, respectively). There were no differences in prevalence of diabetes mellitus or hyperlipidemia among the four groups. The plasma F<SUB>1+2</SUB> levels were significantly higher in the A group, C group, and AS group than in the N group (p<0.05, p<0.01, and p<0.01, respectively), although there were no differences in F<SUB>1+2</SUB> levels among the three lacunar groups. These findings suggest that a hypercoagulable state exists in lacunar infarction with or without symptoms and may, at least in part, contribute to the development of the lacunar infarction.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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