Lipid peroxidation after subarachnoid hemorrhage. Efficacy of intracisternal methylprednisolone.:Efficacy of intracisternal methylprednisolone
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The effect of intracisternal administration of the steroid hormone, methylprednisolone sodium succinate (MP), was studied from the viewpoint of the lipid peroxidation after subarachnoid hemorrhage (SAH). In our double-hemorrhage canine model, the value of the lipid peroxides rose significantly in the cerebrospinal fluid (CSF) supernatant on Day 4, and their accumulation also increased in the arterial wall on Day 7. Intrathecal injection of MP suppressed the deposition of lipid peroxides in both the subarachnoid space and the arterial wall. These findings suggest that lipid peroxidation may be involved in the pathogenesis of vasospasm after SAH, and that intracisternal MP may suppress lipid peroxidation in the arterial wall and prevent the vasopasm syndrome.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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