Two cases of ischemic cerebrovascular disease associated with hereditary protein C deficiency.
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We describe two cases of ischemic cerebrovascular disease associated with hereditary protein C deficiency. Patient 1 was a 34-year-old man who developed sudden onset of dysarthria and weakness of both hands. Cerebral magnetic resonance imaging (MRI) studies and angiography demonstrated no abnormalities. Three days later, the patient's clinical manifestations completely disappeared. His plasma levels of protein C antigen and functional activity were 53% and 51%, respectively. His father, who had had his left leg amputated due to arterial thrombosis, and his sister also revealed protein C deficiency. Patient 2 was a 62-year-old women who was admitted with progressive right hemiparesis. MRI disclosed an infarction in the left corona radiata. On admission, her protein C antigen level and functional activity were found to be reduced to 48% and 43%, respectively. Investigation of her family members revealed protein C deficiency in her two children as well. Warfarin was used for long-term propbylaxis in conjunction with short-term heparin administration to prevent warfarin-induced skin necrosis. Subsequently, there have been no arterial thrombotic events. We conclude that protein C deficiency should be examined for in patients with an unexplained cerebral infarction, even if they are relatively old, in order to treat them and possibly other family members at risk.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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