Progression of carotid atherosclerosis and stroke recurrence. B-mode ultrasonographic assessment.:B-mode ultrasonographic assessment
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概要
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The relationship between the recurrence of ischemic stroke and the progression of carotid atherosclerosis was evaluated by B-mode carotid ultrasonography. The subjects comprised 90 consecutive patients with more than one carotid plaque (average age 64.6 ± 9.4 y.o.) who could be examined repeatedly after average intervals of 14.2 ± 6.0 months. Twelve patients (Group A) developed thrombotic stroke episodes during the study period, while the remaining 78 patients (Group N) did not. There was no significant difference in the severity of carotid atherosclerosis (plaque score : PS) between the two goups at the first observation. The control levels of risk factors for cerebral infarction during the period, and the percentage of patients on anti-platelet therapy were also not significantly different. The progression rate of PS was greater in Group A than in Group N (1.83 ± 1.30 vs. 0.95 ±1.03) (p <0.05). When comparisons were made among each site of the carotid arteries, the difference was remarkable just above (p<0.05) and below (p < 0.01) the flow divider. Furthermore, when Group A was divided into three subgroups with lacunar infarction (LI), TIA and atherothrombotic infarction (AI), the PS progression was significantly greater in TIA (p < 0.01) and AI (p<0.05) than in Group N. From the standpoint of the risk factors considered, good control of hypertension significantly suppressed the PS progression (p <0.001). Additionally, anti-platelet agent administration was considered to have a potential to suppress the progression of carotid lesions. The present findings clarified that the recurrence of thrombotic stroke (TIA and AI) was closely related to the progression rate of carotid atherosclerosis, and the progression rate appeared to be suppressed by good treatment of hypertension.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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