Elevated levels of basic fibroblast growth factor in the cerebrospinal fluid of patients with moyamoya disease.
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The level of basic fibroblast growth factor (bFGF) in the cerebrospinal fluid was measured by a two-sites sandwich enzyme immunoassay in 18 patients with moyamoya disease, 12 patients with atheros-clerotic occlusive cerebovascular disease involving the internal carotid or the middle cerebral arteries, and 15 patients with spinal dise disease. In the moyamoya patients, bFGF was found in 16 out of the 18 cerebrospinal fluid samples with a mean value of 85.5 pg/ml. In 4 patients with moyamoya disease, cerebrospinal fluid samples obtained during contralateral surgery performed 3 or 4 weeks after the first procedure also contained high levels of bFGF. bFGF was detected in only 5 out of the 12 patients with atherosclerotic occlusive cerebrovascular disease; however, the mean value was below the detection limit. In all the patients with disc disease, bFHG was not detected. Postoperative angiograms demonstrated the effectiveness of indirect bypass procedures in moyamoya patients whose cerebrospinal fluid contained a high level of bFGF, but any patient below the detection limit of bFGF was refractory to the indirect bypass procedures. An elevated level of bFGF may play an important role in the pathogenesis of moyamoya disease.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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