Evaluation of the acute recovery of brain energy metabolism in ischemia-reperfusion model of mongolian gerbils.
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The relationship between the duration of cerebral ischemia and the acute recovery in brain energy metabolism was studied in 18 adult Mongolian gerbils using P-31 magnetic resonance spectroscopy (MRS). Brain pH (=pHi), phosphocreatine (PCr) /inorganic phosphate (Pi) ratio, /3-ATP content (%) and β-ATP/Pi ratio were evaluated.<BR>Transient forebrain ischemia was produced by a clipping of bilateral common carotid arteries for 30 min (n=6), 60 min (n=6), or 90 min (n=6).<BR>The P-31 MRS was measured before clipping and after 30-, 60- and 90-min of reperfusion, respectively.<BR>The pHi recovered rapidly to the level of pre-ischemia following reperfusion without showing significant differences in mean pHi values among the three groups. After reperfusion, PCr/Pi ration, β-ATP content (%), and β-ATP/Pi ratio recovered gradually but never returned to the pre-ischemic level in each groups of ischemia. There were significant differences between 90-min ischemia group and 30- or 60-min one for the extent of the acute recovery in PCr/Pi ratio (p<0.01 and p<0.05, respectively). There were significant differences between 30-min group and 90-min one for the extent of the acute recovery in β-ATP/Pi ratio (p<0.01-0.05), respectively.<BR>The results suggest that β-ATP/Pi ratio is the most sensitive parameter for the evaluation of the acute recovery of brain energy metabolism after reperfusion of the forebrain ischemia in Mongolian gerbils.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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