Experimental wall dissection in the common carotid artery of the rabbit. A histopathological study.:A histopathological study
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One of the cause of cerebrovascular accident in young adult is a wall dissection of the cerebral artery. There are a few case reports of wall dissection of the cerebral artery, but no experimental studies using animal models have been reported in the literature. We devised a new experimental model in the rabbit, and 55 cases of arterial wall dissection of common carotid artery were prepared. Chronological observations were done for a maximum of 3 months as follows : the animals were sacrificed at intervals (1 hour, 1 week, 1 month and 3 months) to examine the local pathophysiological changes and follow the healing processes.<BR>Wall dissection was confirmed histologically in 25 animals and divided into three groups : re-entry formation (REF), pocket formation (PF), and lumen occlusion (LO) groups. The pathophysiological conditions of the REF and PF groups were in the progressing stage for the first 1 month after the onset, followed by the healing process during the next 2 months (stable stage in histological condition). Full recovery was already confirmed at 3 months after the onset in several cases. Thrombus formation was found in the angled corner of pseudolumen of the dissecting wall within 1 week in the earliest, suggesting the possibility of a subsequent cerebral embolism. In almost all 5 cases which showed LO, the LO was confirmed within a few hours after the onset, which indicated that complete occlusion of the vessel may occur in the very acute stage. A ruptured dissecting aneurysm was found in only one case; which was confirmed histologically in the post-mortem examination.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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