Alteration of plasma renin activity in acute cerebrovascular disease
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概要
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There have been only a few reports concerning the alteration of plasma renin activity in acute cerebrovascular disease. The purpose of this study was to investigate the alteration of plasma renin activity and its interrelationship with age, the type of stroke, clinical severity of stroke, urinary catecholamine excretion and blood pressure in acute cerebrovascular disease.<BR>For assay of renin activity, blood samples were collected from every patients within 48 hours of an acute insult, and then periodical sampling of blood was carried out every seven days during three weeks of observation. Urinary catecholamine concentration was measured fluorometrically.<BR>Of 21 patients with acute cerebrovascular disease who were examined in this study, 16 patients had cerebral infarction and the remaining 5 patients had intracerebral hemorrhage.<BR>The following results were obtained in this study.<BR>1) Significant inverse correlation (P<0.001) was found between age and plasma renin activity in acute cerebrovascular disease.<BR>2) The mean value for renin activity was higher in intracerebral hemorrhage than in cerebral infarction but the difference was not statistically significant.<BR>3) The patients with cerebral infarction whose clinical state was mild, had higher values for plasma renin activity than moderate or severe cases.<BR>4) The blood pressure recorded at the time of blood sampling had no correlation with plasma renin activity, nor did the urinary catecholamine excretion.<BR>5) No remarkable change was observed in plasma renin activity through the course of cerebrovascular disease from the onset to three weeks after.<BR>In conclusion, there was a close relationship between plasma renin activity and age in the patient with acute cerebrovascular disease.<BR>It was suggested that in any investigation of plasma renin activity, aging factor should not be ignored even in acute phase of cerebrovascular disease.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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