Triiodothyronine T3 Ameliorates Proinflammatory Cytokines in Septic Rat Model.
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Purpose: We clarified the effects of triiodothyronine on proinflammatory cytokines in a septic rat model. Materials and Methods: Sprague-Dawley rats weighing 320-420g underwent cecal ligation and puncture (CLP) to induce sepsis and were grouped randomly as (1) control group: CLP only, (2) L group: CLP/T3 3ng/hr, and (3) H group: CLP/T3 15ng/hr. T3 was administered subcutaneously by osmotic pump. Blood samples were obtained 24 hours after laparotomy from abdominal aorta and IL-1β, TNF-α, IL-6, IL-8, and free T3 were measured. Results and Discussion: Proinflammatory cytokine production was suppressed by T3 administration especially in the L group. Free T3 was also maintained within the normal range by T3 administration. All animals survived in the L and H groups, whereas 3 died in the control group. We concluded that T3 replacement offers a good outcome in a septic rat model because it suppresses proinflammatory cytokines.
- 一般社団法人 日本救急医学会の論文
一般社団法人 日本救急医学会 | 論文
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