Regulation of Energy Metabolism by Peculiar Processing of Glucagon in Intestines in Surgically Stressed Patients.
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We studied the insulin: glucagon (I/G) molar ratio and kinetics of glucagon and glucagon-related peptides assessed by radioimmunoassay and gel filtration chromatography and assessed energy metabolic status using indirect calorimetry in 16 patients with acute abdominal disorders who underwent emergency surgery (group P). We discuss glucagon processes and the correlation of glucagon kinetics and energy metabolism in surgically stressed status. Ten healthy subjects were enrolled as controls (group C). After surgery, the I/G ratio significantly decreased compared to that of group C. In 11 of the 16 patients in group P, a peculiar glicentin-like peptide (GLLP: MW about 8000) other than pancreatic glucagon was seen in gel filtration chromatography, which was absolutely not seen in group C, and was presumed to have been generated from the glucagon precursor in the intestine in a quite different glucagon process. In results of indirect calorimetry, nonprotein respiratory quotients (RQ) in 11 patients in whom GLLP were seen in chromatography were significantly lower than those in 5 patients without GLLP. In conclusion, the kinetics and processing of glucagon in most surgically stressed patients was quite different from those of healthy subjects, which may greatly influence and regulate energy metabolism after surgery.
- 一般社団法人 日本救急医学会の論文
一般社団法人 日本救急医学会 | 論文
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