Suppression of Guinea Pig Intestinal Tract Contraction by Lipopolysaccharide.
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概要
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Lipopolysaccharide (LPS) is considered a cause of sepsis-induced ileus. Reduced intestinal movement induced by LPS is regarded as a response mediated by nitric oxide (NO) or cytokine, but the mechanism of the direct action of LPS on intestinal smooth muscle remains uncertain. In this study, the intestinal tract from a guinea pig injected intraperitoneally with LPS was used to investigate the mechanisms of suppression of intestinal smooth muscle by LPS. An isolated taenia caecum strip or a circular muscle strip of caecum was set in an organ bath, and the isometric tone measured. Histamine-induced contraction, ACh-induced contraction, and 40mM KCl-induced contraction were inhibited in the longitudinal muscle and circular muscle of the caecum in the LPS-treated group compared to untreated controls. The suppressive effect of LPS on 40mM KCl-induced contraction was blocked by pretreatment with charybdotoxin, a selective K+-channel blocker. These results suggest that the mechanisms of suppression of intestinal contraction by LPS may include inhibition of the voltagedependent Ca2+-channel or opening of the Ca2+- dependent K+- channel on the smooth muscle cell membrane.
- 一般社団法人 日本救急医学会の論文
一般社団法人 日本救急医学会 | 論文
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