Pro-Inflammatory Cytokine Release by Human Peripheral Blood Mononuclear Cells under Moderate Hypothermia.
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Background: Recently, the therapeutic values of moderate hypothermia (MH), (32-33°C), have been reappraised for protection against severe brain injury. MH appears to increase susceptibility to bacterial infection, the control of which is considered to be a key factor for successful use of this technique. We reported previously that the functions of polymorphonuclear cells and monocytes are impaired under MH. In this study we compared pro-inflammatory cytokine release from peripheral blood mono-nuclear cell (PBMC) at 33°C and 37°C. Methods: PBMCs were harvested from 3 healthy adults. TNF-α, IL-1β and IL-6 concentrations were measured at 1, 2, 3, 6, 12, 24 and 48 hours after the stimulation by S. cerevisiae or lipopolysaccharide (LPS) by ELISA, Results: At 3, 6 and 12 hours after S. cerevisiae stimulation, and at 1 and 2 hours after LPS stimulation, TNF-α release was significantly, lower at MH than at 37°C. However, there was no difference in IL-1β and IL-6 concentrations after the S. cerevisiae stimulation at 33°C and 37°C. Conclusion: These data suggest that decreased TNF-α release might play a major role in masking manifestations of an infectious process during hypothermic therapy.
- 一般社団法人 日本救急医学会の論文
一般社団法人 日本救急医学会 | 論文
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