Helminthic Effects of Homomycin, with Reference to Elimination of the Tape Worm (Raillietina cesticillus) and Round Worm (Ascaridia galli)
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概要
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Data presented here indicate that homomycin, a kind of antibiotic isolated from Streptomyces noboritoensis, is effective to eliminate the tape worm (Raillietina cesticillus) and round worm (Ascaridia galli) from the small intestine of chicks.1) Five cockerels were infested with the tape worm by oral administration of parasitized beetles at 6 weeks of age. Segments discharged from the tape worm were excreted in the droppings, and counted at 3 P. M., 5 P. M., and 7 P. M., every day. Subsequent to feeding with a basal ration for 7 days after establishment of the infestation, they were fed with the ration containing 0.003% of homomycin for 40 days.Number of segments excreted per day in 5 cases attained 17 to 131, at 1 to 3 days before homomycin feeding. Earlier stoppage of the excretion occured in one case at the 21 st day on the feeding. In the remaining 4 cookerels, number of segmants excreted gradually decreased at the 19th to 28th day, and finally no segments excreted at the 40th day.Three days after feeding with the basal ration, while still no excretion continued, they were autopsied. Entire elimination of the tape worm was found in one case. Twenty of 24 tape worms survived in 4 cookerels were not fully grown, and less than 35mm in their length (Exp. I).2) In the experiment II, three cockerels were fed with the ration containing 0.006% of homomycin 7 days after establishment of infestation to the tape worm at 4 weeks of age. Homomycin feeding was conducted for 29 days.At the 23rd to 29th day on the homomycin feeding, no excretion of segments occured, and continued for 9 to 10 days when chicks used were fed with the basal ration after the homomycin feeding.In next trial of experiment II, 1 to 2 gram of 0.3% homomycin was orally administered to these 3 chicks, in which excretion of segments again started, being fed with the basal ration. This procedure was repeated 12 times for 45 days. Eventually, no discharge of segments resulted for 10 days before autopsy. It revealed that entire elimination of the tape worms was established.When homomycin was orally administered one time, a prominent increase in number of segments was observed on the following day. It might be suggested that homomycin induced emaciated conditions in the tape worm through acceralated discharge of segments. If the emaciation progressed follwoing after the prolonged administration of homomycin, even the scolex of the tape worm was excreted in the dropping.3) Five cockerels and 5 hens naturally infested with the round worm (Ascaridia galli) were fed with the ration containing 0.003% of homomycin. Number of the worm eggs per gram of the dropping of birds (EPG) attained to 0 levels during 3 to 44 days on the homomycin feeding, depending upon EPG levels before the feeding. The one case, when autopsied two days alter one determination of EPG 0, showed to fail entire elimination of worms. In 8 cases repeatedly observed EPG 0 before autopsy, no worms survived in the small intestine in 6 cases of them, while a few number of male worms alone did in 2 cases (Exp. III).
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日本家禽学会 | 論文
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