Effects of Thyroidectomy on Serum Levels of Growth Hormone, Insulin-Like Growth Factor (IGF)-1 and IGF-Binding Activity in Dwarf and Normal Chickens.
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Surgical thyroidectomy tended to increase circulating concentrations of growth hormone (GH) in normal Rhode Island Red chickens (Gifu 15 line) but not in dwarf ones (Gifu 20 line). The operation significantly reduced serum IGF-1 concentrations in normals but resulted in an increasing tendency in dwarfs. Serum IGF-binding activity decreased following thyroidectomy in dwarfs. Basal levels of IGF-binding activity were 3-times higher in dwarfs than in normals, presumably reflecting low basal concentrations of IGF-1 in dwarfs. The results suggest that circulating concentrations of IGF-1 as well as those of GH are influenced by thyroid status and dwarfing gene dw.
- 日本家禽学会の論文
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