Two-way selections for survival time of allografts in chickens.

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Two-way selection for the survival time of allografts in chickens was carried out over eight generations. The foundation stocks used for selection were composed of only B11 B11 genotype at the major histocompatibility B locus. The graft from the long survival line was used for testing the survival time of allografts for both long (L) and short (S) survival lines. The selection was effective in the L line, but not necessarily effective in the S line. The differences between the L and S lines increased with each successive generation of selection except with the second generation. The realized herita-bility was comparatively high, with a mean value of 0.334. At the seventh generation of selection, the proportion of survival allografts in the L line was 48.5% at 90 days after transplantation and that in the S line was zero. However, when another line (GVHR line) was used as donor line, the proportions of survival grafts in the L and S lines were only 12.5 and 4.0%, respectively. In comparison of graft-versus-host competence at the seventh generation of selection, the mean splenomegaly index of the L line was significantly larger than that of the S line. The immune response to sheep red blood cells was also compared in the L and S lines at the fifth generation of selection. No line difference was found.(Jpn. Poult. Sci., 27: 337-345, 1990)
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