Antigen-specific genetic control of the immune response associated with the major histocompatibility B locus in chickens.

概要

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Immune responses in chickens to sheep red blood cell (SRBC), bovine red blood cell (BRBC), human serum albumin (HSA), dog serum albumin (DSA) and rabbit serum albumin (RSA) were compared among the major histocompatibility B genotypes, B9/B9, B9/B11 and B11/B11. Relative antibody titers to SRBC, HSA and DSA were B9/B9<B9/B11≈B11/B11. The differences between B9/B9 and the other two genotypes were significant statistically (P<0.05) in these antibody titers. On the contrary, immune responses to RSA and BRBC showed the inverse relationships among the B genotypes, namely B9/B9≈B9/B11>B11/B11 in the case of RSA and B9/B9>B9/B11≈B11/B11 in the case of BRBC (P<0.05). The genetic differences of anti-RSA titer were due to the 2-mercaptoethanol (2-ME) resistant antibody (IgG) titer, as shown by a treatment of antisera with 2-ME.It was suggested that the genetic control of the immune response by the B locus genes in chickens might involve the difference in the immunoglobulin class produced.
日本家禽学会の論文