Adequate dietary level of pyrimethamine as a positive control in a hatchability test.
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概要
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A positive control diet in a hatchability test to assess teratogenic effect of a sampleshould be such that hens take the diet and lay fertile eggs continuously. Furthermore, acertain number of healthy and deformed chicks must be obtained to judge teratogenic effect.Therefore, dietary level of pyrimethamine which is known to be teratogenic and intended touse as a positive control in the hatchability test, should be carefully studied beforehand.Hens fed a diet containing 500 ppm of pyrimethamine for 6 days lost appetite and stoppedlaying. Their appetite and egg production did not recover at 19th day after lowering dietarypyrimethamine level to 250 ppm.Hens fed a diet containing 100 ppm of pyrimethamine lost appetite gradually and stoppedlaying at 14 days after feeding the diet. Their feed intake at the end of the 27-day experimental period was 87g/head/day, comparing with 111g of hens fed a control diet.Hens fed a diet containing 50ppm of pyrimethamine laid continuously, but a trend ofgradual decreae of feed intake and egg production was observed. At the end of the experimental period, their feed intake and egg production were 79g/head/day and 56%, respectively.Ten fertile egg out of 11 laid by the hens fed the diet containing 50 ppm of pyrimethaminestopped growing after 5 days in an incubator, while only one fertile egg out of 9laid by thecontrol hens stopped growing.Adequate dietary level of pyrimethamine to get enough fertile eggs for a hatchability testin which a certain number of normal and deformed chicks could be obtained was suspected tobe less then 20 ppm.
- 日本家禽学会の論文
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