Synergism of antithyroid agent and estrogen in the induction of experimental fatty livers in growing chicks.
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概要
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Lipid and triglyceride content in liver and plasma and plasma transaminase activity were determined in 14-day-old male chicks given graded levels of propylthiouracil (PTU, 0, 0.025, 0.05 and 0.10%) and/or dienestrol diacetate (DD, 0, 0.04, 0.08 and 0.16%) in diet with 4×4 factorial arrangement for 13 days. Plasma transaminase activity was increased by feeding PTU or PTU+DD. Feeding PTU or DD induced significant increase of liver weight and lipid and triglyceride contents in the liver and plasma. Marked hepatic steatosis and hyperlipidemia were caused by concurrent administration of PTU (0.025%) and DD (0.08-0.16%) and those were gradually reduced with increasing PTU in the diet. It is suggested that experimental fatty livers are induced by synergetic actions of antithyroid agent and estrogen in growing chicks.
- 日本家禽学会の論文
日本家禽学会 | 論文
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