Residue and Disappearance of Dietary Kanamycin in the Blood, Muscle, Liver and Bile of Growing Chicks

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Diets containing various levels from 20 to 16, 000μg potency of kanamycin per g diet were fed to meat-type male chicks of 4-week-old for 4 weeks, and 5 chicks each from each lot were sacrificed at the end of kanamycin feeding to get samples of the blood, breast muscle, liver and bile. Thereafter, to the rest of the chicks fed 16, 000μg kanamycin/g diet, kanamycin-free diet was fed, and 5 chicks each were sacrificed at 0, 3, and 6 hours and 1, 2, 3, 5, and 7 days. Content of kanamycin in the samples was determined microbiologically using Bacillus subtilis ATCC 6633.No residue was detected in the blood, muscle and liver of the chicks on 20μg of kanamycin/g diet.Except the residual kanamycin in the muscle, kanamycin contents in the blood, liver and bile at the end of kanamycin feeding were in proportion to dietary kanamycin levels. Residual kanamycin in the muscle increased after the withdrawal of dietary kanamycin, while those in the blood, liver and bile decreased rapidly.The disappearance pattern of residual kanamycin in the chick's body was peculiar and different from those of the antibiotics tested previously. Application of 3-compartment model to explain the disappearance pattern of kanamycin was discussed.
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