Prognostic value of expression of cyclin dependent kinase inhibitor p21 and lung resistance protein as predicting factors in breast cancer.

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The purpose of the study was to inverstigate whether cyclin dependent kinase inhibitor p21 (p21) and lung resistance protein (LRP) could be predicting factors for recurrence after surgery for breast cancer. Immunostainings of p53, p21, and LRP were carried out to breast tissues which had been curatively resected. Prognostic factors were searched by means of multivariate anylysis. In a Cox proportional hazard model, p21 and LRP were factors affecting the recurrence. Patients with p21(-) and LRP(+) developed postoperative recurrence in a high frequency. Of patients administered anticancer drugs, the desease-free suvical rate in those with p21(-) was significantly low and all patients with p21(-) and LRP(+) developed recurrence. Of patients having received postoperative irradiation, a significant difference was seen in the disease-free survical rate between groups with p21(+) and p21(-). In conclusion, expression of p21(+) and LRP can each be an independent prognostic factor. And a combination of p21(+) and LRP(-) predict the best prognosis along with favourable response to chemoradiotherapy following surgery. On the centary a combination of p21(-) and LRP(+) meet disappointing response to chemoradiotherapy.
日本臨床外科学会の論文