EFFECTS OF POTASSIUM CANRENOATE ON PLASMA MAGNESIUM CONCENTRATION IN ABDOMINAL SURGERY

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Plasma magnesium (Mg) concentrations were measured before and after operations in 51 patients undergoing abdominal surgery. Twenty-four patients were administered potassium canrenoate 8 mg/kg immediately after induction of anesthesia, and the other 27 served as controls. The mean plasma Mg concentrations in the control group were 1.74±0.37 mg/100 ml prior to surgery, 1.50±0.36 on the first postoperative day and 1.57±0.33 on the second postoperative day. Postoperative values remained significantly lower than the preoperative value. In the administration group, in contrast, plasma Mg concentrations were 1.77±0.28 preoperatively, 1.66±0.25 on the first postoperative day and 1.77±0.27 on the second postoperative day. Although the first postoperative value in this group was significantly lower than the preoperative value, it was restored to the control level on the second postoperative day. These results suggest that plasma Mg concentration was decreased after abdominal surgery and that administration of potassium canrenoate is useful in order to prevent the decrease in plasma Mg concentrations.
日本臨床外科学会の論文