ON THE INFLUENCE OF THE ADMINISTRATION OF AMINO ACIDS UPON THE DISTRIBUTION OF PORPHY-RIN BODIES IN TISSUES:II. THE INFLUENCE OF THE ADMINISTRATION OF ε-AMINO CAPROIC ACID AND RELATED SUBSTANCES

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1. ε-amino caproic acid increases markedly the metalloporphyrin of various tissues other than intestine, skin, lungs, cerebrum and bone and decreases the porphyrin of whole blood and the porphyrin bodies of urine. 2. Caproic acid is, in general, a factor that decreases more or less tissue metalloporphyrin. 3. In case, an amino group is substituted to α- or ε-position of caproic acid, marked difference is observed in the effect on tissue metal-loporphyrin according to the position of the substitution. The sub-stitution to ε-position causes an increase of the metalloporphyrin and the substitution to α-position bring about an increase in the cases of a half number of tissues investigated and a decrease in the cases of other half. 4. The effect of α, ε-diamino caproic acid on tissue metallopor-phyrin is either the algebraic sum of the effects of α-substitution and of e-substitution or depends mainly upon the effect of either one, especially on that of α-substitution. 5. There is such an aspect in the physiological action of ε-amino caproic acid and its related substances as to be explained by the change in the tissue metalloporphyrin.
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