Human Histone Deacetylase SIRT 2 Interacts with the Homeobox Transcription Factor HOXA 10

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概要

• 論文の詳細を見る

• Histone deacetylases are required for transcriptional repression in eukaryotes. Saccharomyces cerevisiae has several histone deacetylases, of which ySir2p is the most conserved throughout evolution. Currently, there is no report on the interacting protein partner of a human Sir2 homolog, SIRT 2. Here we show for the first time that SIRT 2 interacts with the homeobox transcription factor, HOXA 10, which was identified in a two-hybrid screen. Interactions were confirmed by co-immunoprecipitation from in vitro translations as well as in human cell-free extracts. Taken together with mouse knockout studies, our results raise the intriguing possibility that SIRT 2 plays a role in mammalian development.

• 社団法人 日本生化学会の論文

著者

• Vassilev Alex

  Laboratory Of Molecular And Growth Regulation National Institute Of Child Health And Human Developme

• Howard Bruce

  Laboratory Of Molecular And Growth Regulation National Institute Of Child Health And Human Developme

• Swanson Mark

  Laboratory Of Eukaryotic Gene Regulation National Institute Of Child Health And Human Development Na

• Bae Nancy

  Laboratory Of Molecular And Growth Regulation National Institute Of Child Health And Human Developme

• Howard Bruce

  Laboratory of Molecular and Growth Regulation, National Institute of Child Health Development, National Institutes of Health

関連論文

• Human Histone Deacetylase SIRT2 Interacts with the Homeobox Transcription Factor HOXA10
• Human Histone Deacetylase SIRT 2 Interacts with the Homeobox Transcription Factor HOXA 10

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