Identification and Characterization of CaMKP-N, Nuclear Calmodulin-Dependent Protein Kinase Phosphatase.
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概要
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Calmodulin-dependent protein kinase phosphatase (CaMKP) dephosphorylates and concomitantly deactivates multifunctional Ca2+/calmodulin-dependent protein kinases (CaMKs), such as CaMKI, CaMKII, and CaMKIV. In the present study, a nuclear CaMKP-related protein, CaMKP-N, was identified. This protein consisted of 757 amino acid residues with a calculated molecular weight of 84, 176. Recombinant CaMKP-N dephosphorylated CaMKIV. The activity of CaMKP-N requires Mn2+ ions and is stimulated by polycations. Transiently expressed CaMKP-N in COS-7 cells was localized in the nucleus. This finding together with previous reports regarding localization of CaMKs indicates that CaMKP-N dephosphorylates CaMKIV and nuclear CaMKII, whereas CaMKP dephosphorylates CaMKI and cytosolic CaMKII.
- 社団法人 日本生化学会の論文
著者
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Kameshita Isamu
Department Of Biochemistry Asahikawa Medical College
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Takeuchi Masayuki
Department Of Biochemistry Asahikawa Medical College
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Okuno Sachiko
Department Of Biochemistry Asahikawa Medical College
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Fujisawa Hitoshi
Department Of Biochemistry Asahikawa Medical College
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Ishida Atsuhiko
Department of Biochemistry, Asahikatca Medical College
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Kitani Takako
Department of Biochemistry Asahikawa Medical College
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