Apolipoprotein B Production and Very Low Density Lipoprotein Secretion by Calf Liver Slices.
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概要
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Secretion of triglycerides by the liver in ruminants as components of very low density lipoproteins particles is low as compared with that in primates or rodents. The rate-limiting steps for the hepatic export of very low density lipoproteins have been studied in liver slices to determine the origin of the low lipotropic capacity of calf liver compared to that of rat liver. The rates of production of apolipoprotein B (apo B) and albumin as well as the rate of secretion of VLDL-apolipoproteins were measured during 12-h incubation of liver slices in organo-culture using [35S] methionine-cysteine labeling. Hepatic apo B production was similar in the two animal species but the VLDL-apolipoprotein secretion rate for calf liver slices amounted to only 20% of that observed for rat liver slices. Although calf and rat liver slices synthesized similar amounts of total protein, the hepatic production of albumin, measured in cells and media, was much higher in calf than rat liver slices (around 2.7-fold), whereas the rate secretion of albumin was similar in the two species. Our results showed that the slow rate of secretion of VLDL by calf liver cells was not consecutive to a low rate of synthesis of apo 13 but rather to a defect in VLDL assembly and/or secretion.
- 社団法人 日本生化学会の論文
著者
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Durand Denys
Laboratoire Croissance Et Metabolismes Des Herbivores Unite Metabolismes Energetique Et Lipidique In
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GRAULET Benoit
Laboratoire Croissance et Metabolismes des Herbivores, Unite Metabolismes Energetique et Lipidique,
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Bauchart Dominique
Laboratoire Croissance Et Metabolismes Des Herbivores Unite Metabolismes Energetique Et Lipidique In
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Samson-bouma Marie-elisabeth
Inserm Unite 327 Faculte De Medecine X. Bichat
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Greffat-Mouty Dominique
Laboratoire Croissance et Métabolismes des Herbivores, Unité Métabolismes Energétique et Lipidique, Institut National de la Recherche Agronomique Centre de Recherches Clerm
関連論文
- Fatty Acid Metabolism and Very Low Density Lipoprotein Secretion in Liver Slices from Rats and Preruminant Calves
- Apolipoprotein B Production and Very Low Density Lipoprotein Secretion by Calf Liver Slices
- Apolipoprotein B Production and Very Low Density Lipoprotein Secretion by Calf Liver Slices.