Identification and Subcellular Localization of a Novel Mammalian Dynamin-Related Protein Homologous to Yeast Vpslp and Dnmlp.

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概要

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• The dynamin family of GTP-binding proteins are implicated in vesicular transport. These include mammalian dynamins I, II, III, and yeast Vps1p and Dnm1p. Dynamin is involved in the formation of clathrin-coated vesicles at the plasma membrane. On the other hand, Vps1p and Dnm1p appear to be involved in transport from the late Golgi compartment to vacuoles and in an endocytic process, respectively. In this study, we identified a novel human protein, named Dnm1p/Vps1p-like protein (DVLP). It resembled more closely Dnmlp and Vpslp than dynamins not only in the primary structure but also in the domain organization. DVLP mRNA was expressed ubiquitously, suggesting that this protein plays a fundamental role in cellular function. Immunofluorescence analysis of cells expressing epitope-tagged DVLP revealed that it showed a diffused perinuclear staining pattern that was not superimposed on that of the marker protein for the Golgi apparatus, trans-Golgi network, lysosomes, endosomes, or endoplasmic reticulum. These data suggest that DVLP is not involved in the formation of known coated vesicles.

• 社団法人 日本生化学会の論文

著者

• Shinotsuka Chisa

  Institute Of Biological Sciences University Of Tsukuba

• Nakayama Kazuhisa

  Institute Of Biological Sciences And Gene Experiment Center University Of Tsukuba

• Shin Hye-Won

  Institute of Biological Sciences and Gene Research Center, University of Tsukuba

• Shin Hye-Won

  Institute of Sciences, University of Tsukuba

• Torii Seiji

  lnstitute of Applied Biochemistry, University of Tsukuba

• Murakami Kazuo

  lnstitute of Applied Biochemistry, University of Tsukuba

関連論文

• Identification and Subcellular Localization of a Novel Mammalian Dynamin-Related Protein Homologous to Yeast Vps1p and Dnm1p^1
• Structure and Intracellular Localization of Mouse ADP-Ribosylation Factors Type 1 to Type 6 (ARF1-ARF6)
• Dynamin II Is Involved in Endocytosis but Not in the Formation of Transport Vesicles from the trans-Golgi Network
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• ADP-Ribosylation Factor-1 Is Sensitive to N-Ethylmaleimide
• Identification and Characterization of Novel Isoforms of COP I Subunits.
• Identification and Subcellular Localization of a Novel Mammalian Dynamin-Related Protein Homologous to Yeast Vpslp and Dnmlp.
• Dynamin II Is Involved in Endocytosis but Not in the Formation of Transport Vesicles from the trans-Golgi Network.

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