X-Irradiation Activates the Drosophila 1731 Retrotransposon LTR and Stimulates Secretion of an Extracellular Factor That Induces the 1731-LTR Transcription in Nonirradiated Cells.

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概要

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• Using constructs expressing the reporter gene under the control of the entire or deleted long terminal repeats (LTRs) of 1731, a Drosophila melanogaster retrotransposable element, we show that 1731-LTR is activated by X-irradiation in a dose- and time-dependent manner, and that a sequence located in the U3 region of these LTRs is required. The cis-acting element conferring X-responsiveness shows similarities to kappaB (κB)-like binding sequence. In response to X-irradiation, S2 Drosophila cells produced an extracellular factor which activates the 1731-LTR in nonirradiated cells. This factor was detected both when transfected cells were cocultured with inducing cells and when a conditioned medium taken from irradiated cultures was added.

• 社団法人 日本生化学会の論文

著者

• Best-belpomme Martin

  Iua Cnrs 1135 Universite P. Et M. Curie

• Faure Eric

  Ecologie Et Biologie Evolutive Institut De Chimie Biologique Universite De Provence

• Champion Serge

  Cnrs 1924 Faculte Des Pharmaciens

• Best-Belpomme Martin

  IUA CNRS 1135, Université P. et M. Curie

関連論文

• X-Irradiation Activates the Drosophila 1731 Retrotransposon LTR and Stimulates Secretio of an Extracellular Factor That Induces the 1731-LTR Transcription in Nonirradiated Cells
• X-Irradiation Activates the Drosophila 1731 Retrotransposon LTR and Stimulates Secretion of an Extracellular Factor That Induces the 1731-LTR Transcription in Nonirradiated Cells.

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