Effect of Angiotensin on Renal Function of the Dog
スポンサーリンク
概要
- 論文の詳細を見る
Angiotensin (5 ng/kg/min and 50 ng/kg/min) was infused directly into the left renal artery of anesthetized dogs in order to examine its effects on the renal func-tion. Urinary volume, creatinine clearance (GFR), PAH-clearance (RPF) and electrolyte excretion were decreased by infusion of angiotensin in a small dose. On the other hand extreme reductions of urinary volume, GFR, RPF and electrolyte excretion were observed immediately after the beginning of angiotensin infusion in a large dose, and were followed by gradual increases in these parameters during the administration of angiotensin (tachyphylaxis). In four out of six cases, urinary volume and sodium excretion surpassed the control values with increased extraction fraction of sodium. These results suggested that angiotensin affected the renal function mainly through two mechanisms: Firstly, the vasoconstrictive action of angiotensin on the renovascular system causes decrease in urinary output, and secondly the direct action on the tubular system causes natriuresis.
- 東北ジャーナル刊行会の論文
東北ジャーナル刊行会 | 論文
- Effects of Ketamine and Propofol on the Ratio of Interleukin-6 to Interleukin-10 during Endotoxemia in Rats
- α2-Adrenergic Modulation of Glucagon and Insulin Secretions in Sheep
- Molecular Analysis of the Pathogenesis of Autoimmune Insulitis in NOD Mice
- Effects of Thymoxamine in Ouabain-Induced Arrhythmias in Dogs
- T Cell Hypofunctions and Glomerular Sclerotic and Angiogenic Changes Found Both in Rats Received Unilateral Nephrectomy plus Transplantation of Syngeneic Mesenteric Lymph Nodes and in Rats Received Unilateral Nephrectomy plus Splenectomy