Studies on the Temperature of the Gastrointestinal Tract:Sixth Report Response of the Intragastric Temperature to Various Drugs (Part II)

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Response of the intragastric temperature of healthy men to subcutaneous injection of benzylimidazoline, prostigmine and histamine and to intravenous injection of benzylimidazoline and tetraethylammonium bromide was studied, simultaneously with those of the pulse rate, blood pressure and gastric juice; and the following facts were confirmed.1. The intragastric temperature drops by benzylimidazoline, tetraethylammonium bromide and histamine, and rises by prostigmine.2. The drop by benzylimidazoline is generally proportional to the injected dosis but the type is different by the mode of injection-by the subcutaneous injection the drop gradually increases and by the intravenous it rapidly appears and recovers.3. The drop by tetraethylammonium bromide is approximately the same as that by intravenously injected benzylimidazoline.4. The drop by histamine is greatest and both the onset and the recovery are most rapid.5. The rise by prostigmine is preceded by a certain period when no significant change is observed.6. The change in the intragastric temperature is in intimate relation with the blood flow and is determined by an aggregation of the pulse rate and blood pressure.7. The change in the intragastric temperature is not related with that in the gastric free acidity.
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