Studies on the Temperature of the Gastrointestinal Tract:Fifth Report Response of the Intragastric Temperature to Various Drugs

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Response of. the intragastric temperature of healthy men to subcutaneous injection of histamine, adrenaline, pilocarpine and atropine was studied simultaneously with those of the axillary temperature, pulse rate, blood pressure and gastric juice; and the following facts were confirmed.1. The intragastric temperature drops by the four drugs.2. The drop by histamine is transient contrary to those by adrenaline and pilocarpine and the drop by atropine is preceded by a slight rise.3. The maximum drop is large by histamine and pilocarpine and small by adrenaline and atropine.4. Onset of the drop is more rapid by histamine than by pilocarpine and adrenaline and is slowest by atropine.5. Combination of the maximum drop and the time for reaching it, is different by the four drugs.6. Change in the axillary temperature is generally parallel with that in the intragastric.7. Change in the pulse rate is in intimate relation with that in the intragastric temperature. Blood flow is one of the most important factors in the change in the intragastric temperature.8. By histamine and pilocarpine which strongly stimulate the gastric secretion, the intragastric temperature is intensely lowered.
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